Photoactive chemical 'restores' sight
نویسندگان
چکیده
منابع مشابه
Complete chemical structure of photoactive yellow protein: novel thioester-linked 4-hydroxycinnamyl chromophore and photocycle chemistry.
The unique ability of photoactive proteins to capture and use energy from a photon of light depends on the chromophore, its linkage to the protein, and the surrounding protein environment. To understand the molecular mechanisms by which a chromophore and protein interact to undergo a light cycle, we are studying photoactive yellow protein (PYP), a 14-kDa water-soluble photoreceptor from Ectothi...
متن کاملUltrafast dynamics of isolated model photoactive yellow protein chromophores: "Chemical perturbation theory" in the laboratory.
Pump-probe and pump-dump probe experiments have been performed on several isolated model chromophores of the photoactive yellow protein (PYP). The observed transient absorption spectra are discussed in terms of the spectral signatures ascribed to solvation, excited-state twisting, and vibrational relaxation. It is observed that the protonation state has a profound effect on the excited-state li...
متن کاملOn the absorbance changes in the photocycle of the photoactive yellow protein: a quantum-chemical analysis.
Spectral changes in the photocycle of the photoactive yellow protein (PYP) are investigated by using ab initio multiconfigurational second-order perturbation theory at the available structures experimentally determined. Using the dark ground-state crystal structure [Genick, U. K., Soltis, S. M., Kuhn, P., Canestrelli, I. L. & Getzoff, E. D. (1998) Nature (London) 392, 206-209], the pipi* transi...
متن کاملPHOTOACTIVE CHLOROPHYLL-an IN PHOTOSYNTHESIS
Herrn Prof. Dr. L. Z e r v a s , Athen, danken wir für wertvolle Hinweise, Herrn Dr. J. G l i e m a n n , Kopen hagen, für die biologischen Teste. Dem Gesamtverband der Textilindustrie in der Bundesrepublik Deutschland, der Arbeitsgemeinschaft Industrieller Forschungsver einigungen e. V. und dem Bundesministerium für Wirtschaft danken wir für die Förderung des For schungsvorhabens 1318. Fern...
متن کاملFirst sight
But despite the portrait and interrogation by doctors in London, Jesty never received credit for his pioneering work, with all the credit and financial rewards going to Jenner with his many friends in the medical establishment in London who spent considerable time and money refining the technique. Jenner never accepted that he had been preempted over vaccination by Jesty. However, the Jestys fr...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2012
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.2369